Alon Saguy was awarded a Fulbright Postdoctoral Fellowship to pursue his research project titled “Spike sorting of Neuropixel probe signals via contrastive learning”. In his research, Alon will examine electrical signals recorded in the brains of mammals and humans using Neuropixel probes. Alon will develop novel signal processing methods to track the neural activity across multiple brain regions in single neuron resolution and decode brain function.

During his PhD, under the supervision of Professor Yoav Shechtman, Alon focused on the challenge of tracking the dynamics of sub-cellular structures in super-resolution. Recently, he developed a groundbreaking method to visualize live-cell dynamics with several orders of magnitude better spatial and temporal resolution than the standard imaging methods.

Alon’s prominent publications include:

A. Saguy, O. Alalouf, N. Opatovski, S. Jang, M. Heilemann, Y. Shechtman. “DBlink: Dynamic localization microscopy in super spatiotemporal resolution via deep learning”. Nature Methods 20 (12), 1939-1948 (2023)

A. Saguy, T. N. Baldering, L. E. Weiss, E. Nehme, C. Karathanasis, M. S. Dietz, Mike Heilemann, Yoav Shechtman. “Automated analysis of fluorescence kinetics in single molecule localization microscopy data reveals protein stoichimetry”. The Journal of Physical Chemistry B 125 (22), 5716-5721 (2021)

D. Allen, L. E. Weiss, A. Saguy, M. Rossenberg, O. Lancu, O. Matalon, C. Lee, K. Beider, A. Nagler, Y. Shechtman, A. Hendel. “High-throughput imaging of CRISPR and recombinant adeno-associated virus induced DNA damage response in human hematopoietic stem and progenitor cells”. The CRISPR Journal 5 (1), 80-94 (2022)